The Venom That Kills Also Cures: Inside India's Antivenom-Making Process Using the 'Big Four' Snakes and HorsesScience
12 Aug 2026, 10:27 pm (2 days ago)· 0

The Venom That Kills Also Cures: Inside India's Antivenom-Making Process Using the 'Big Four' Snakes and Horses

Nearly 40,000 people die of snakebite in India every year, and 36,000 of those deaths are caused by just four snake species. Here's how their venom is turned into life-saving antivenom with the help of horses.

A report from West Champaran has shed light on how the medicine that saves lives after a snakebite is, quite literally, made from snake venom itself. Across the world, antivenom is prepared using the venom of exactly those snake species responsible for the highest number of bites and deaths. In India, four such snakes are behind nearly 40,000 deaths every year.

The 'Big Four' snakes behind most snakebite deaths

According to Abhishek, an expert who has worked on wildlife for close to two decades, antivenom in India is developed keeping four snake species in mind. These are the spectacled cobra, also known locally as gehuwan, the Russell's viper, the saw-scaled viper and the common krait. Data shows that roughly 40,000 people die of snakebite in India every year, and 36,000 of those deaths are caused by just these four species. That is why they are collectively referred to as the Big Four.

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How horses turn venom into a life-saving antidote

The process of making antivenom is carried out with great care. Venom is first extracted safely from the Big Four snakes. A small and carefully controlled amount of this venom is then injected into the bodies of specially bred horses, not ordinary ones, but horses raised specifically for this purpose. Once the venom enters their system, their immune system begins producing antibodies to fight it. These antibodies are later drawn from the horses and separated from the plasma in a laboratory. The plasma is then purified to produce the antivenom that hospitals eventually administer to snakebite patients.

Why even a small mistake can prove fatal

Abhishek explains that antivenom, at its core, is still venom, just processed and prepared as an antibody before use. He points out that even the slightest lapse in handling it can cost a life. His advice is straightforward: ordinary people should never try to handle snake venom or its antidote themselves, and this work should be left entirely to trained experts.

Questions & Answers

What is antivenom made from?
Antivenom is made from snake venom itself, which is injected into horses and drawn out as antibodies from their immune system.
Which snakes are used to make antivenom in India?
The spectacled cobra (gehuwan), Russell's viper, saw-scaled viper and common krait, known together as the Big Four.
Why are these four snakes called the Big Four?
Because of the roughly 40,000 annual snakebite deaths in India, 36,000 are caused by just these four species.
What role do horses play in making antivenom?
A safe amount of venom is injected into horses, whose immune system produces antibodies that are later extracted and processed into antivenom.
Should ordinary people handle snake venom themselves?
No, expert Abhishek says even a small mistake in handling it can be fatal, so it should be left to trained professionals.
How many people die of snakebite in India each year?
About 40,000 people die of snakebite in India every year.

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